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Clinical Evidence: Semaglutide's Proven Cardiovascular Outcomes The SUSTAIN-6 trial (2016) was the first major study to confirm semaglutide's heart-protective effects in patients with type 2 diabetes and established cardiovascular disease

21,22 Dipeptidyl peptidase-4 (DPP4), also known as CD26, plays a crucial role in both protective immunity and immune tolerance